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α1A-AR Degrader 9c
$898
Only 1000 item(s) left in stock.
Products Details
Product Description
– α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research[1].
Web ID
– HY-147100
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C38H43N11O11
References
– [1]Li Z, et al. First small-molecule PROTACs for G protein-coupled receptors: inducing α1A-adrenergic receptor degradation. Acta Pharm Sin B. 2020 Sep;10(9):1669-1679.
CAS Number
– 2863635-02-1
Molecular Weight
– 829.82
SMILES
– O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN4N=NC(C(N5CCN(C6=NC(N)=C7C=C(OC)C(OC)=CC7=N6)CC5)=O)=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor;PROTACs
Isoform
– α adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling;PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
