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Products Details
Product Description
– β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC50 value of 5.7 nM – 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects[1].
Web ID
– HY-155313
Shipping
– Room temperature
Molecular Formula
– C59H92N8O19
References
– [1]Wang Y, et al. Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment. Bioorg Med Chem Lett. 2023 Oct 15;95:129493.
Molecular Weight
– 1217.40
SMILES
– CN(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](OC(N(CCN(C)C(OCC2=CC([N+]([O-])=O)=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O3)C=C2)=O)C)=O)C4=CC=CC=C4)=O)CCC1)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Others
Pathway
– Others
Product type
– Reference compound
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