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(±)-Praeruptorin A
Price range: 70 CAD through 445 CAD
Products Details
Product Description
– 1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
Web ID
– T4S1419
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H22O7
References
– Jeongtae Y , Sikwon C , Jun R B , et al. Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin.[J]. Journal of Natural Products, 2015, 78(4):776-82.
CAS Number
– 73069-25-7
Molecular Weight
– C21H22O7
Compound Purity
– 0.9973
SMILES
– CC=C(C)C(=O)O[C@@H]1[C@H](OC(C)=O)c2c(OC1(C)C)ccc1ccc(=O)oc21
Pathway
– Cytoskeletal Signaling|||Membrane transporter/Ion channel|||MAPK|||Metabolism|||PI3K/Akt/mTOR signaling
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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