Cell Cycle & Checkpoint Inhibitors

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Select a target to explore available cell cycle and checkpoint compounds. Counts reflect unique products in our collection.

The cell cycle is a tightly regulated series of events that drives cell growth and division. It consists of four main phases — G1, S, G2, and M — each governed by specific cyclin-dependent kinases (CDKs) and their cyclin partners. Small-molecule modulators of these kinases have become indispensable tools for studying proliferation, differentiation, and growth arrest in vitro.

Checkpoints act as surveillance mechanisms that ensure each phase is completed accurately before the cell proceeds. The G1/S checkpoint assesses DNA integrity, the intra-S checkpoint monitors replication fidelity, and the G2/M checkpoint verifies that DNA replication is complete. Compounds targeting checkpoint kinases such as Chk1, Chk2, ATR, and Wee1 are widely used to investigate how cells respond to genotoxic stress and replication errors.

Mitotic regulators — including Aurora kinases, Polo-like kinases (PLKs), and kinesins — coordinate chromosome segregation and cytokinesis. Dysregulation of these proteins is a hallmark of many disease models studied in pre-clinical research. Our collection provides researchers with a comprehensive toolkit for probing every stage of the cell cycle and its checkpoint controls.