Afatinib
Add to CompareAdded to Compare

Download Files:

Afatinib

SKU T21312-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 506 CAD

Products Details

Product Description

– Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively.

Web ID

– T21312

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H25ClFN5O3

Citations

– 1. Liang J, Bi G, Sui Q, et al.Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma.Cell Reports.2024, 43(2). 2. Wei X, Zhang G, Liu Q, et al.Almonertinib and alflutinib show novel inhibition on rare EGFR S768I mutant cells.Clinical and Translational Oncology.2024: 1-16. 3. Long Y, Jia X, Chu L.Insight into the structure, function and the tumor suppression effect of gasdermin E.Biochemical Pharmacology.2024: 116348. 4. Zhang C, Sun Y X, Yi D C, et al.Neoadjuvant sintilimab plus chemotherapy in EGFR-mutant NSCLC: Phase 2 trial interim results (NEOTIDE/CTONG2104).Cell Reports Medicine.2024 5. Tu R, Ma J, Chen Y, et al.USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression.Cell Death & Disease.2024, 15(10): 749.

References

– Wong CH, et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC). Am J Cancer Res. 2015 Nov 15;5(12):3588-99.

CAS Number

– 850140-72-6

Molecular Weight

– C24H25ClFN5O3

Compound Purity

– 0.9988

SMILES

– N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Pathway

– Autophagy|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Phenytoin sodium
Phenytoin sodium Price range: 72 CAD through 85 CAD
1 g1 mL * 10 mM (in DMSO)500 mg

1000 in stock

Select options
3-Acetylcoumarin
3-Acetylcoumarin 46 CAD
1 mL * 10 mM (in DMSO)500 mg

1000 in stock

Select options
AChE-IN-23
AChE-IN-23 Price range: 66 CAD through 150 CAD
100 mg200 mg50 mg

1000 in stock

Select options
4-Ethoxycoumarin
4-Ethoxycoumarin 46 CAD
1 g1 mL * 10 mM (in DMSO)

1000 in stock

Select options
7-Methoxy-1-tetralone
7-Methoxy-1-tetralone Price range: 46 CAD through 56 CAD
1 g1 mL * 10 mM (in DMSO)

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });