Download Files:
AZD4547
Price range: 53 CAD through 618 CAD
Products Details
Product Description
– AZD4547 is an FGFR family inhibitor. AZD4547 selectively inhibits FGFR1 phosphorylation and suppresses cancer cell proliferation through inhibition of FGFR1 signaling, and is able to act on FGFR1 (IC50:0.2 nM), FGFR2 (IC50:2.5 nM), FGFR3 (IC50:1.8 nM) and FGFR4 (IC50:165 nM). IC50:165 nM).[2]
Web ID
– T1948
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H33N5O3
Citations
– 1. Yang Y L, Cao L B, He W R, et al. Endocytosis triggers V-ATPase-SYK–mediated priming of cGAS activation and innate immune response. Proceedings of the National Academy of Sciences. 2022, 119(43): e2207280119.
2. Pu X, Ye Q, Cai J, et al. Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas. Cell death & disease. 2021 Mar 11;12(3):256. doi: 10.1038/s41419-021-03548-4.
3. Feng Y, Zhang D, He G, et al. AZD4547 and the Alleviation of Hepatoma Cell Sorafenib Resistance via the Promotion of Autophagy. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2022, 22(18): 3107-3113.
References
– Gavine PR, et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res, 2012, 72(8), 2045-2056.
CAS Number
– 1035270-39-3
Molecular Weight
– C26H33N5O3
Compound Purity
– 0.9988
SMILES
– COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
Target
– Others
Pathway
– Angiogenesis|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
1000 in stock
