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U-73343
Price range: 61 CAD through 531 CAD
Products Details
Product Description
– U-73343 is an inactive analog of U-73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC.
Web ID
– TQ0159
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H42N2O3
Citations
– 1. Ye F, Jiang Y, Zong Y, et al. PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal mast cells. Immunology Letters. 2022
2. Cui S, Suo N, Yang Y, et al.The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2023: 1-12.
References
– Muto Y, et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther. 1997 Sep;282(3):1379-88.
CAS Number
– 142878-12-4
Molecular Weight
– C29H42N2O3
Compound Purity
– 0.9906
SMILES
– COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN1C(=O)CCC1=O
Pathway
– Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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