– GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2′,3′-cyclic-phosphate or 3′-phosphate ends to RNA with 5′-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splicing ‘dirty’ DNA breaks, characterized by 3′-phosphate (or cyclic-phosphate) and 5′-hydroxy ends that cannot be sealed by classical DNA ligases.