WH244
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WH244

SKU T88099-10 mg Category Brand:

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Product Description

– WH244 is a second-generation dual degrader (PROTAC) targeting BCL-2 and BCL-xL proteins. It effectively degrades these proteins with high specificity, exhibiting a DC50 of 0.6 nM for BCL-xL and 7.4 nM for BCL-2. By promoting ubiquitination and subsequent proteasomal degradation of these proteins, WH244 restores apoptotic pathways in cells. The compound shows strong antitumor activity.

Web ID

– T88099

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C83H105ClF3N13O11S4

CAS Number

– 2941088-96-4

Molecular Weight

– C83H105ClF3N13O11S4

SMILES

– C(C1=C(CC[C@](CN2CCN(C(CN3CCN(CC(N[C@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@@](C)(C)C)=O)CC3)=O)CC2)(C)C1)C7=CC=C(Cl)C=C7)N8CCN(CC8)C9=CC=C(C(NS(=O)(=O)C%10=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN%11[C@@]%12(C[C@](C%11)(OC%12)[H])[H])CSC%13=CC=CC=C%13)C=C%10)=O)C=C9

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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