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GW6471
Price range: 48 CAD through 1,397 CAD
Products Details
Product Description
– GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.
Web ID
– T8486
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C35H36F3N3O4
Citations
– 1. Wang R, Zhao J, Jin J, et al. WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC. Lipids in Health and Disease. 2022, 21(1): 1-18.
References
– Abu Aboud O, et al. Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells. PLoS One. 2013 Aug 7;8(8):e71115.
CAS Number
– 880635-03-0
Molecular Weight
– C35H36F3N3O4
Compound Purity
– 0.9949
SMILES
– CCC(=O)NC[C@H](Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)NC(C)=C/C(=O)c1ccc(cc1)C(F)(F)F
Pathway
– Metabolism|||DNA Damage/DNA Repair
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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