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Products Details
Product Description
– Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC linking Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity in FLT3-ITD+ acute myeloid leukemia (AML) cells. It promotes ubiquitin-proteasome-dependent degradation of FLT3-ITD and KIT proteins, thereby inhibiting their downstream signaling pathways and presenting research potential in FLT3-ITD+ AML [1].
Web ID
– T81421
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C39H38FN9O6
CAS Number
– 2732969-67-2
Molecular Weight
– C39H38FN9O6
SMILES
– O=C1NC=2C=CC=C(F)C2C(N)=C1C3=NC4=CC=C(C=C4N3)N5CCN(C(=O)CCCCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)CC5
Pathway
– PROTAC
Product type
– PROTAC
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