Download Files:
EGFR-IN-60
Price range: 3,424 CAD through 5,632 CAD
Products Details
Product Description
– EGFR-IN-60 is an effective, orally active, safe antitumor agent. EGFR-IN-60 significantly inhibits EGFRWT (IC50: 83 nM), EGFRT790M (IC50: 26 nM), EGFRL858R (IC50: 53 nM) and JAK3 (IC50: 69 nM). IN-60 inhibited H1975 cells carrying the EGFRT790M mutation (IC50: 1.32 μM) and A431 cells overexpressing EGFRWT (IC50: 4.96 μM). EGFR-IN-60 increased the Bax/Bcl-2 ratio, which induced apoptosis induction and cell death.
Web ID
– T63769
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C28H28Cl2N6O
CAS Number
– 2699877-43-3
Molecular Weight
– C28H28Cl2N6O
SMILES
– O=C1C=2C(C3=C(NC2CC(C)(C)C1)N=CN(N=CC4=CC=C(N(C)C)C=C4)C3=N)C5=C(Cl)C(Cl)=CC=C5
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
