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Talazoparib
Price range: 56 CAD through 1,173 CAD
Products Details
Product Description
– Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).
Web ID
– T6253
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H14F2N6O
Citations
– 1. Hou X, Tian M, Ning J, et al.PARP inhibitor shuts down the global translation of thyroid cancer through promoting Pol II binding to DIMT1 pause.International Journal of Biological Sciences.2023, 19(12): 3970.
2. Mateos-Pujante A, Jiménez M C, Andreu I.Assessment of the PARP inhibitor talazoparib photosafety profile.Biomedicine & Pharmacotherapy.2023, 167: 115593.
3. Kamaletdinova T, Zong W, Urbánek P, et al.Poly (ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development.Cells.2023, 12(16): 2078.
4. Kiehlmeier S, Rafiee M R, Bakr A, et al. Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia. Leukemia. 2021 Nov;35(11):3127-3138. doi: 10.1038/s41375-021-01235-z. Epub 2021 Apr 28.
5. Liu C, Li J, Xu F, et al.PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer.Molecular Cancer.2024, 23(1): 111.
6. Liu S, Deng P, Yu Z, et al.CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer.Advanced Science.2024: 2403782.
7. Lodovichi S, Nepomuceno T C, Woods N T, et al.SART1 modulates Poly-(ADP-Ribose) chain accumulation and PARP1 chromatin localization.iScience.2024
References
– Wilkerson PM, et al. Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer. Oncotarget. 2017 Jan 24;8(4):6057-6066.
CAS Number
– 1207456-01-6
Molecular Weight
– C19H14F2N6O
Compound Purity
– 0.9992
SMILES
– Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1
Pathway
– Chromatin/Epigenetic|||DNA Damage/DNA Repair
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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