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Mirdametinib
Price range: 75 CAD through 1,512 CAD
Products Details
Product Description
– Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis.
Web ID
– T6189
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C16H14F3IN2O4
Citations
– 1. Guo Z, Guo L, Qin J, et al. A single transcription factor facilitates an insect host combating Bacillus thuringiensis infection while maintaining fitness. Nature Communications. 2022, 13(1): 1-15.
2. Guo Z, Kang S, Sun D, et al. MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host. Nature Communications. 2020 Jun 12;11(1):3003. doi: 10.1038/s41467-020-16608-8.
3. Kuang, Junqi, et al. SS18 regulates pluripotent-somatic transition through phase separation.. Nature Communications. 2021 Jul 2;12(1):4090. doi: 10.1038/s41467-021-24373-5.
4. Wang W, Ren S, Lu Y, et al. Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production. The EMBO Journal. 2021 Jun 1;40(11):e106771. doi: 10.15252/embj.2020106771. Epub 2021 Apr 28.
5. Lin R, Zhai Z, Kuang J, et al. H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition. Cell & Bioscience. 2022, 12(1): 1-14
6. Guo Z, Kang S, Wu Q, et al. The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host. PLoS pathogens. 2021, 17(9): e1009917.
7. Chen F, Zhang M, Feng X, et al. Discovery of a Novel Long Noncoding RNA Lx8-SINE B2 as a Marker of Pluripotency. Stem Cells International. 2021 Feb 6;2021:6657597. doi: 10.1155/2021/6657597. eCollection 2021.
8. Yu Y, Li X, Jiao R, et al.H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development.Cell & Bioscience.2023, 13(1): 1-20.
9. Yang Y, Xiao L, Xue Y, et al.ZBTB7A regulates primed‐to‐naïve transition of pluripotent stem cells via recognition of the PNT‐associated sequence by Zinc Fingers 1–2 and recognition of γ‐globin− 200 gene element by Zinc Fingers 1–4.The FEBS Journal.2023
10. Wan C, Huang Y, Xue X, et al.HELQ deficiency impairs the induction of primordial germ cell‐like cells.FEBS Open Bio.2024
References
– Ciuffreda L, et al. Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations. Neoplasia. 2009 Aug;11(8):720-31.
CAS Number
– 391210-10-9
Molecular Weight
– C16H14F3IN2O4
Compound Purity
– 0.9991
SMILES
– OC[C@@H](O)CONC(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F
Pathway
– MAPK|||Apoptosis|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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