Selinexor (KPT-330)
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Selinexor (KPT-330)

SKU T6106-2 mg Category Brand:

Price range: 62 CAD through 770 CAD

Products Details

Product Description

– Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma.

Web ID

– T6106

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H11F6N7O

Citations

– 1. Han Y, Hu A, Qu Y, et al.Covalent targeting the LAS1-NOL9 axis for selective treatment in NPM1 mutant acute myeloid leukemia.Pharmacological Research.2023: 106700. 2. Liu H, Shen C, Li H, et al.Discovery of Potent Covalent CRM1 Inhibitors Via a Customized Structure-Based Virtual Screening Pipeline and Bioassays.Journal of Chemical Information and Modeling.2024

References

– Etchin J, et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol. 2013 Apr;161(1):117-27.

CAS Number

– 1393477-72-9

Molecular Weight

– C17H11F6N7O

Compound Purity

– 0.9985

SMILES

– FC(F)(F)c1cc(cc(c1)C(F)(F)F)-c1ncn(C=C/C(=O)NNc2cnccn2)n1

Pathway

– Membrane transporter/Ion channel

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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