BAY-218
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BAY-218

SKU T5622-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 54 CAD through 2,224 CAD

Products Details

Product Description

– Bindarit (AF2838)is an aryl hydrocarbon receptor (AHR) antagonist with IC50 of 39.9 nM in the human glioblastoma U87 cell line. BAY-218 inhibition of AhR stimulates pro-inflammatory monocyte and T cell responses in vitro and drives anti-tumor immune responses, leading to reduced tumor growth in vivo.

Web ID

– T5622

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H17ClFN3O3

References

– Ilona Gutcher, Christina Kober, Lars Roese,et al.Abstract 1288: Blocking tumor-associated immune suppression with BAY-218, a novel, selective aryl hydrocarbon receptor (AhR) inhibitor[J].10.1158/1538-7445.AM2019-1288 Published July 2019.

CAS Number

– 2162982-11-6

Molecular Weight

– C20H17ClFN3O3

Compound Purity

– 0.9954

SMILES

– C[C@@H](CO)NC(=O)c1cc(nn(-c2cccc(F)c2)c1=O)-c1ccc(Cl)cc1

Pathway

– Immunology/Inflammation|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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