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Asciminib
Price range: 91 CAD through 2,224 CAD
Products Details
Product Description
– Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM).
Web ID
– T5177
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H18ClF2N5O3
Citations
– 1. Zhang C, Huang C, Xia H, et al. Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition. Cell Death & Disease. 2022, 13(7): 1-15
2. Cheng S, Jin P, Li H, et al. Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model. Frontiers in Pharmacology. 2021: 2866.
References
– Wylie AA, et al. The allosteric inhibitor ABL2001 enables dual targeting of BCR-ABL1. Nature. 2017 Mar 30;543(7647):733-737.
CAS Number
– 1492952-76-7
Molecular Weight
– C20H18ClF2N5O3
Compound Purity
– 0.9793
SMILES
– C(NC1=CC=C(OC(Cl)(F)F)C=C1)(=O)C2=CC(=C(N=C2)N3CC[C@@H](O)C3)C=4C=CNN4
Pathway
– Cytoskeletal Signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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