AZ32
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AZ32

SKU T4443-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 82 CAD through 1,251 CAD

Products Details

Product Description

– AZ32 is an orally bioavailable, blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for the ATM enzyme and an IC50 of 0.31 μM for ATM in cells.

Web ID

– T4443

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H16N4O

Citations

– 1. Liu K, Li Y C, Chen Y, et al. AZ32 reverses ABCG2-mediated multidrug resistance in colorectal cancer. Frontiers in Oncology. 2021, 11: 1764.

References

– Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647.

CAS Number

– 2288709-96-4

Molecular Weight

– C20H16N4O

Compound Purity

– 0.9994

SMILES

– CNC(=O)c1ccc(cc1)-c1cnc2cnc(cn12)-c1ccccc1

Pathway

– PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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