TM5441
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TM5441

SKU T4254-1 mg Category Brand:

Price range: 54 CAD through 2,336 CAD

Products Details

Product Description

– TM5441 is an orally bioavailable fibrinogen activator inhibitor-1 inhibitor that inhibits several cancer cell lines with IC50 values ranging from 13.9 to 51.1 μM.It induces intrinsic cell death in several human cancer cells and attenuates Nω-nitro-1-arginine methyl ester-induced cardiac hypertension and vascular senescence.

Web ID

– T4254

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H17ClN2O6

Citations

– 1. Zhang W, Yang S, Chen D, et al. SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis by sponging miR-942-5p and activating PI3K/Akt signaling. Cellular and Molecular Life Sciences. 2022, 79(1): 1-16.

References

– Placencio VR, et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10(7):e0133786.

CAS Number

– 1190221-43-2

Molecular Weight

– C21H17ClN2O6

Compound Purity

– 0.9909

SMILES

– OC(=O)c1cc(Cl)ccc1NC(=O)COCC(=O)Nc1cccc(c1)-c1ccoc1

Pathway

– Apoptosis|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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