AST 487
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AST 487

SKU T4053-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 50 CAD through 1,952 CAD

Products Details

Product Description

– AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.

Web ID

– T4053

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H30F3N7O2

Citations

– 1. Agarwal N, Zhou Q, Arya D, et al. AST-487 Inhibits RET Kinase Driven TERT Expression in Bladder Cancer. International Journal of Molecular Sciences. 2022, 23(18): 10819.

References

– Akeno-Stuart N, et al. The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells. Cancer Res. 2007 Jul 15;67(14):6956-64.

CAS Number

– 630124-46-8

Molecular Weight

– C26H30F3N7O2

Compound Purity

– 0.9817

SMILES

– C(C1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC=3C=C(NC)N=CN3)C=C2)=O)C=C1)N4CCN(CC)CC4

Pathway

– Cytoskeletal Signaling|||Angiogenesis|||Apoptosis|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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