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Products Details
Product Description
– Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a prodrug of Combretastatin A-1, is a tubulin-binding microtubule polymerization inhibitor targeting the colchicine-binding site. By inducing tubulin depolymerization, it inhibits the Wnt/β-catenin pathway and deactivates AKT, possessing both anti-tumor and anti-vascular properties.
Web ID
– T40367
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H18Na4O12P2
References
– Stratford MRL, et, al. Quantitative determination of the anticancer prodrug combretastatin A1 phosphate (OXi4503, CA1P), the active CA1 and its glucuronide metabolites in human urine and of CA1 in plasma by HPLC with mass spectrometric detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:1-6.
CAS Number
– 288847-34-7
Molecular Weight
– C18H18Na4O12P2
SMILES
– [Na].COc1ccc(C=C/c2cc(OC)c(OC)c(OC)c2)c(OP(O)(O)=O)c1OP(O)(O)=O
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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