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MS67
1,526 CAD
Only 1000 item(s) left in stock.
Products Details
Product Description
– MS67 is a potent and selective degrader of WD40 repeat domain protein 5 (WDR5) with a dissociation constant (Kd) of 63 nM, exhibiting no activity against protein methyltransferases, kinases, G-protein-coupled receptors (GPCRs), ion channels, and transporters, and notably demonstrating significant anticancer properties.
Web ID
– T39976
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C52H59F4N9O7S
References
– Xufen Yu, et al. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med. 2021 Sep 29;13(613):eabj1578.
CAS Number
– 2407452-77-9
Molecular Weight
– C52H59F4N9O7S
SMILES
– C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CNC(=O)c1ccc(F)c(c1)-c1ccc(N2C[C@H](C)N(C)[C@H](C)C2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1)C(C)(C)C)c1ccc(cc1)-c1scnc1C
Pathway
– PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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