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Thailanstatin A
Price range: 315 CAD through 2,032 CAD
Products Details
Product Description
– Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM). It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC.
Web ID
– T38889
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C28H41NO9
References
– Puthenveetil S, et al. Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads. Bioconjug Chem. 2016;27(8):1880-1888.
CAS Number
– 1426953-21-0
Molecular Weight
– C28H41NO9
Compound Purity
– 0.9935
SMILES
– C[C@H](OC(C)=O)C=C/C(=O)N[C@@H]1C[C@H](C)[C@H](CC=C(/C)C=C[C@H]2O[C@H](CC(O)=O)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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