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Product Description
– 14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.
Web ID
– T37261
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H40N2O6S
CAS Number
– 75290-64-1
Molecular Weight
– C25H40N2O6S
SMILES
– CCCCC[C@H](O)[C@H](SC[C@H](N)C(=O)NCC(O)=O)C=CC=CC=C/CC=C/CCCC(O)=O
Pathway
– Others
Product type
– Small Compound
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