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Product Description
– 7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .
Web ID
– T36998
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C27H46O3
References
– Soroosh, P., Wu, J., Xue, X., et al.Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiationProc. Natl. Acad. Sci. USA111(33)12163-12168(2014)
CAS Number
– 240129-43-5
Molecular Weight
– C27H46O3
SMILES
– C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Pathway
– Others
Product type
– Small Compound
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