Download Files:
APY29
Price range: 58 CAD through 1,904 CAD
Products Details
Product Description
– APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
Web ID
– T3654
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C17H16N8
Citations
– 1. Yuan J, Yao C, Tang J, et al. Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021, 462: 152962.
References
– Wang, L., Perera, B., Hari, S., Bhhatarai, B., Backes, B., & Seeliger, M. et al. (2012). Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nature Chemical Biology, 8(12), 982-989. doi: 10.1038/nchembio.1094
CAS Number
– 1216665-49-4
Molecular Weight
– C17H16N8
Compound Purity
– 0.9846
SMILES
– C1CC1c1cc(Nc2ccnc(Nc3ccc4nc[nH]c4c3)n2)n[nH]1
Pathway
– Cell Cycle/Checkpoint
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
