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Products Details
Product Description
– BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.
Web ID
– T36138
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H39O3P
CAS Number
– 1306684-90-1
Molecular Weight
– C22H39O3P
SMILES
– C(CCCCCCCCCCCCCC)C1=CC=C(CP(=O)(O)O)C=C1
Pathway
– Others
Product type
– Small Compound
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