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X-376
Price range: 48 CAD through 979 CAD
Products Details
Product Description
– X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.
Web ID
– T3550
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H25Cl2FN6O3
References
– Caccese M, et al. Current and developing therapies for the treatment of non-small cell lung cancer with ALK abnormalities: update and perspectives for clinical practice. Expert Opin Pharmacother. 2016 Dec;17(17):2253-2266.
CAS Number
– 1365267-27-1
Molecular Weight
– C25H25Cl2FN6O3
Compound Purity
– 0.9872
SMILES
– C[C@@H](Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Target
– Others
Pathway
– Angiogenesis|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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