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Endoxifen (hydrochloride)
$50 – $450
Products Details
Product Description
– Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study[1][2].
Web ID
– HY-18719B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H28ClNO2
References
– [1]Wu X, et al. The tamoxifen metabolite, Endoxifen, is a potent antiestrogen that targets estrogen receptor alpha fordegradation in breast cancer cells. Cancer Res. 2009 Mar 1;69(5):1722-7.|[2]Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park). 2009 Dec;23(14):1233-4, 1236.
CAS Number
– 1197194-41-4
Molecular Weight
– 409.95
Compound Purity
– 98.20
SMILES
– OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)CC)C=C1.[H]Cl
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMSO : ≥ 35 mg/mL|H2O : 1 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– Cytochrome P450;Drug Metabolite;Estrogen Receptor/ERR;Parasite
Isoform
– CYP19
Pathway
– Anti-infection;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
