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Verteporfin
Price range: 54 CAD through 778 CAD
Products Details
Product Description
– Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also induces apoptosis and inhibits autophagy.
Web ID
– T3112
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C41H42N4O8
Citations
– 1. Peng G, Suo S, Cui G, et al. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature. 2019, 572(7770): 528-532.
2. Tang Y, Fang G, Guo F, et al. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell. 2020, 38(1): 115-128. e9.
3. Isfort I, Cyra M, Elges S, et al. SS18-SSX-dependent YAP/TAZ Signaling in Synovial Sarcoma. Clinical Cancer Research. 2019, 25(12): 3718-3731
4. Trautmann M, Cheng Y Y, Jensen P, et al. Requirement for YAP1 signaling in myxoid liposarcoma. EMBO Molecular Medicine. 2019, 11(5): e9889
5. Zhuang Q, Li F, Liu J, et al. Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis. Laboratory Investigation. 2021, 101(2): 258-270.
6. Isfort I, Elges S, Cyra M, et al. Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone. Scientific Reports. 2019, 9(1): 1-9
7. Wang X, Zhu Y, Wu Q, et al.Development of a Cell Culture Model for Inducible SARS-CoV-2 Replication.Viruses.2024, 16(5): 708.
8. Yang B, Xu Z, Qin Y, et al.Exploring the effects of Hippo signaling pathway on rumen epithelial proliferation.BMC Veterinary Research.2024, 20(1): 1-11.
9. Ma R, Bi H, Wang Y, et al.Low concentrations of saracatinib promote definitive endoderm differentiation through inhibition of FAK-YAP signaling axis.Cell Communication and Signaling.2024, 22(1): 1-18.
10. Sun Q, Jiang N, Yao R, et al.An agonist of the adenosine A2A receptor, CGS21680, promotes corneal epithelial wound healing via the YAP signalling pathway.British Journal of Pharmacology.2024
References
– Ma YW, et al. Verteporfin induces apoptosis and eliminates cancer stem-like cells in uveal melanoma in the absence of light activation. Am J Cancer Res. 2016 Dec 1;6(12):2816-2830.
CAS Number
– 129497-78-5
Molecular Weight
– C41H42N4O8
Compound Purity
– 0.9824
SMILES
– COC(=O)CCc1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(O)=O)c5C)[C@]1(C)[C@H](C(=O)OC)C(=CC=C41)C(=O)OC)c(C)c3C=C
Pathway
– Angiogenesis|||Autophagy|||Apoptosis|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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