JNJ-46356479
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JNJ-46356479

SKU T27686-25 mg Category Brand:

Price range: 2,672 CAD through 4,480 CAD

Products Details

Product Description

– JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256.

Web ID

– T27686

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H22F5N5

References

– Cid JM, Tresadern G, Vega JA, de Lucas AI, Del Cerro A, Matesanz E, Linares ML, García A, Iturrino L, Pérez-Benito L, Macdonald GJ, Oehlrich D, Lavreysen H, Peeters L, Ceusters M, Ahnaou A, Drinkenburg W, Mackie C, Somers M, Trabanco AA. Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). J Med Chem. 2016 Aug 31. [Epub ahead of print] PubMed PMID: 27579727.

CAS Number

– 1254979-66-2

Molecular Weight

– C22H22F5N5

SMILES

– C(F)(F)(F)C=1C=2N(C(CC3CC3)=NN2)C=CC1CN4CCN(CC4)C5=C(F)C=C(F)C=C5

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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