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Products Details
Product Description
– β2AR agonist /M-receptor antagonist-1 is a potent dual muscarinic antagonist/beta 2 agonist (MABA). β2AR agonist /M-receptor antagonist-1 potently relaxes either Carbachol (HY-B1208)-induced contraction, in the absence (MABA) or presence of Propranolol (M3; HY-B1208), or Histamine (HY-B1204)-induced contraction (β2)[1][2].
Web ID
– HY-148533
Shipping
– Room temperature
Molecular Formula
– C33H40FN5O5S2
References
– [1]Huihui Ti, et al. Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J Med Chem. 2019 Jul 11;62(13):5944-5978.|[2]Fiorella Pastore, et al.In vitro pharmacological characterization of the novel inhaled bronchodilator CHF6366 acting as dual muscarinic antagonist/β2-agonist (MABA). European Respiratory Journal 2017 50: PA1805.
CAS Number
– 2772700-36-2
Molecular Weight
– 669.83
SMILES
– O=C(C1=CN=C(C(C)C)S1)N2CC3(OCC2)CCN(CC3)CC4=CC(CCNC[C@@H](C5=C6C(NC(S6)=O)=C(C=C5)O)O)=C(C=C4)F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor;mAChR
Isoform
– β adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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