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CH5447240
Price range: 4,112 CAD through 7,360 CAD
Products Details
Product Description
– CH5447240 is an effective Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist for the treatment of Hypoparathyroidism. CH5447240 showed a potent in vitro hPTHR1 agonist effect (EC20: 3.0 nM; EC50: 12 nM). It showed 55% oral bioavailability and a significantly elevated serum calcium level in hypocalcemic model rats.
Web ID
– T25234
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H39N5O4S
References
– Nishimura Y, Esaki T, Isshiki Y, Okamoto N, Furuta Y, Kotake T, Watanabe Y, Ohta M, Nakagawa T, Noda H, Shimizu M, Saito H, Tamura T, Sato H. Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small-Molecule for Treatment of Hypoparathyroidism. J Med Chem. 2018 Jun 22. doi: 10.1021/acs.jmedchem.8b00182. [Epub ahead of print] PubMed PMID: 29932656.
CAS Number
– 1253919-92-4
Molecular Weight
– C26H39N5O4S
SMILES
– O=C1C2(NC(=N1)[C@H]3CC[C@H](C)CC3)CCN(S(CCC4=C(C)C=C(N(C(N)=O)C)C=C4C)(=O)=O)CC2
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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