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Tezacaftor
Price range: 54 CAD through 850 CAD
Products Details
Product Description
– Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
Web ID
– T2263
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H27F3N2O6
Citations
– 1. Jarosz-Griffiths H H, Scambler T, Wong C H, et al. Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis. ELife. 2020, 9: e54556
2. Sondo E, Cresta F, Pastorino C, et al. The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs. International Journal of Molecular Sciences. 2022, 23(6): 3175.
3. Baldassarri M, Zguro K, Tomati V, et al.Gain-and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes.Cells.2022, 11(24): 4096.
4. Tomati V, Costa S, Capurro V, et al.Rescue by elexacaftor-tezacaftor-ivacaftor of the G1244E cystic fibrosis mutation’s stability and gating defects are dependent on cell background.Journal of Cystic Fibrosis.2022
References
– Vertex to host investor conference
CAS Number
– 1152311-62-0
Molecular Weight
– C26H27F3N2O6
Compound Purity
– 0.9994
SMILES
– CC(C)(CO)c1cc2cc(NC(=O)C3(CC3)c3ccc4OC(F)(F)Oc4c3)c(F)cc2n1C[C@@H](O)CO
Pathway
– Membrane transporter/Ion channel|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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