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Products Details
Product Description
– Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the research of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.
Web ID
– HY-144237
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H27ClN4OS
References
– [1]Ergül AG, et al. Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase. Eur J Med Chem. 2022 Mar 5;231:114167.
CAS Number
– 2227434-74-2
Molecular Weight
– 503.06
SMILES
– S=C1OC(C2=CC=C3C(N=C(C(C4=CC=C(CC(C)C)C=C4)C)N3CC5=CC=CC=C5Cl)=C2)=NN1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PGE synthase
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
