Empagliflozin
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Empagliflozin

SKU T1766-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 62 CAD through 467 CAD

Products Details

Product Description

– Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes.

Web ID

– T1766

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H27ClO7

Citations

– 1. Tian G, Yu Y, Deng H, et al. Empagliflozin alleviates ethanol‐induced cardiomyocyte injury through inhibition of mitochondrial apoptosis via a SIRT1/PTEN/Akt pathway. Clinical and Experimental Pharmacology and Physiology. 2021, 48(6): 837-845. 2. Kim P, Kim G Y, Cho M Y, et al. Manufacture and Characterization of Two Distinct Quasi-polymorphs of Empagliflozin. Journal of Crystal Growth. 2020: 125489 3. Ni X, Feng X, Wang Z, et al.Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway.Acta Pharmacologica Sinica.2024: 1-14. 4. Wen Q, Zhang R, Ye K, et al.Empagliflozin rescues pro-arrhythmic and Ca2+ homeostatic effects of transverse aortic constriction in intact murine hearts.Scientific Reports.2024, 14(1): 15683. 5. Yang K, Liang W, Hu H, et al.ESRRA modulation by empagliflozin mitigates diabetic tubular injury via mitochondrial restoration.Cellular Signalling.2024: 111308.

References

– Mihaljević V, et al. Molecular Mechanisms Linking Empagliflozin to Renal Protection in the LLC-PK1 Model of Diabetic Nephropathy. Biomedicines. 2022 Nov 20;10(11):2983.

CAS Number

– 864070-44-0

Molecular Weight

– C23H27ClO7

Compound Purity

– 0.9998

SMILES

– O[C@H]1[C@H](C2=CC(CC3=CC=C(O[C@H]4CCOC4)C=C3)=C(Cl)C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O

Target

– Others

Pathway

– GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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