XL228
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XL228

SKU T17267-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 82 CAD through 981 CAD

Products Details

Product Description

– XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).

Web ID

– T17267

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H31N9O

References

– Cortes J, et al. Preliminary Clinical Activity in a Phase I Trial of the BCR-ABL/IGF- 1R/Aurora Kinase Inhibitor XL228 in Patients with Ph++ Leukemias with Either Failure to Multiple TKI Therapies or with T315I Mutation. Blood 2008 112:3232

CAS Number

– 898280-07-4

Molecular Weight

– C22H31N9O

Compound Purity

– 0.9907

SMILES

– CC(C)c1cc(CNc2nc(Nc3cc([nH]n3)C3CC3)cc(n2)N2CCN(C)CC2)on1

Target

– Others

Pathway

– Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint|||Angiogenesis|||Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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