VER-246608
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VER-246608

SKU T17224-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 77 CAD through 1,230 CAD

Products Details

Product Description

– VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.

Web ID

– T17224

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C28H23ClF2N4O4

CAS Number

– 1684386-71-7

Molecular Weight

– C28H23ClF2N4O4

Compound Purity

– 0.985

SMILES

– Cc1cnc(Cl)nc1-c1ccc(cc1)N(Cc1ccc(CNC(=O)C(F)F)cc1)C(=O)c1ccc(O)cc1O

Target

– Autophagy|||NMDAR

Pathway

– PI3K/Akt/mTOR signaling|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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