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Product Description
– 7-Hydroxy Quetiapine-d8 is the deuterium labeled 7-Hydroxyquetiapine. 7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine[1].
Web ID
– HY-137532S
Shipping
– Room temperature
Molecular Formula
– C21H17D8N3O3S
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Bakken GV, et al. Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Drug Metab Dispos. 2009 Feb;37(2):254-8.
CAS Number
– 1185098-57-0
Molecular Weight
– 407.56
SMILES
– C(COCCO)N1C(C(N(C=2C=3C(SC=4C(N2)=CC=C(O)C4)=CC=CC3)C(C1([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H]
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite;Isotope-Labeled Compounds
Pathway
– Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
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