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VHL Ligand 8
2,384 CAD
Only 1000 item(s) left in stock.
Products Details
Product Description
– VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1, exhibiting DC50 values ranging from 0.2-1 nM [1].
Web ID
– T13958
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C23H29N3O6
References
– Han X, Zhao L, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.
CAS Number
– 2701565-76-4
Molecular Weight
– C23H29N3O6
SMILES
– C([C@H](C(C)C)C=1ON=C(C)C1)(=O)N2[C@H](C(N[C@@H](CC(O)=O)C3=CC=CC=C3)=O)C[C@@H](O)C2
Target
– Others
Pathway
– Others
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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