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Radicicol
285 CAD
Products Details
Product Description
– Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel
Web ID
– T16719
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H17ClO6
References
– Kato M, et al. Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. Structure. 2007 Aug;15(8):992-1004. Epub 2007 Aug 2.
CAS Number
– 12772-57-5
Molecular Weight
– C18H17ClO6
SMILES
– C[C@@H]1C[C@@H]2[C@H](O2)/C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
Target
– Others
Pathway
– Immunology/Inflammation|||MAPK|||Microbiology/Virology|||Cytoskeletal Signaling|||Metabolism|||NF-κB
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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