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Lenalidomide
Price range: 58 CAD through 157 CAD
Products Details
Product Description
– Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the synthesis of PROTAC products.
Web ID
– T1642
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C13H13N3O3
Citations
– 1. Durbin A D, Wang T, Wimalasena V K, et al. EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified NeuroblastomaEP300 Controls Enhancers and MYCN in Neuroblastoma. Cancer Discovery. 2022-12 (3) P730
2. Yang J, Chung C I, Koach J, et al.MYC phase separation selectively modulates the transcriptome.Nature Structural & Molecular Biology.2024: 1-13.
3. Li P, Hu X, Fan Z, et al.Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation.Journal of Hematology & Oncology.2024, 17(1): 77.
References
– Kim K, et al. Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncol Lett. 2013 Feb;5(2):588-592.
CAS Number
– 191732-72-6
Molecular Weight
– C13H13N3O3
Compound Purity
– 0.9991
SMILES
– NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1
Target
– Others
Pathway
– PROTAC|||Apoptosis
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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