Lovastatin
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Lovastatin

SKU T1207-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 360 CAD

Products Details

Product Description

– Lovastatin (MK-803) is an HMG-CoA reductase inhibitor (IC50=3.4 nM). Lovastatin lowers cholesterol and is commonly used as a lipid-lowering agent in the treatment of hypercholesterolemia.

Web ID

– T1207

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H36O5

Citations

– 1. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797. 2. Yang C, Fan S, Wang X, et al. Optimize the combination regimen of Trastuzumab and Nab-paclitaxel in HER2-positive tumors via modulating Caveolin-1 expression by lovastatin. Asian Journal of Pharmaceutical Sciences. 2022 3. Liu Q, Guo L, Qi H, et al. A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer. Cell Death & Disease. 2021, 12(7): 1-11. 4. Wang D, Wang Y, Di X, et al.Cortical tension drug screen links mitotic spindle integrity to Rho pathway.Current Biology.2023 5. Li C, Yao Z, Ma L, et al.Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells.Stem Cell Reports.2023, 18(4): 969-984. 6. Tan X D, Luo C F, Liang S Y.Antihyperlipidemic drug rosuvastatin suppressed tumor progression and potentiated chemosensitivity by downregulating CCNA2 in lung adenocarcinoma.Journal of Chemotherapy.2024: 1-13. 7. Wan M, Zhou J, Xue N, et al.Lovastatin-mediated pharmacological inhibition of Formin protein DIAPH1 suppresses tumor immune escape and boosts immunotherapy response.International Immunopharmacology.2025, 144: 113637. 8. In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

References

– Pahan K, et al. J Clin Invest, 1997, 100(11), 2671-2679.

CAS Number

– 75330-75-5

Molecular Weight

– C24H36O5

Compound Purity

– 0.9992

SMILES

– CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Target

– Others

Pathway

– Autophagy|||Apoptosis|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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