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GRL0617
Price range: 50 CAD through 1,888 CAD
Products Details
Product Description
– GRL0617 is a selective and competitive noncovalent inhibitor of SARS-CoVPLpro and deubiquitinase (IC50: 0.6 μM, Ki: 0.49 μM).
Web ID
– T11464
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H20N2O
Citations
– 1. Yan H, Liu Z, Yan G, et al. A robust high-throughput fluorescence polarization assay for rapid screening of SARS-CoV-2 papain-like protease inhibitors. Virology. 2022
2. Li M, Bei Z C, Yuan Y, et al.In-cell bioluminescence resonance energy transfer (BRET)-based assay uncovers ceritinib and CA-074 as SARS-CoV-2 papain-like protease inhibitors.Journal of Enzyme Inhibition and Medicinal Chemistry.2024, 39(1): 2387417.
References
– Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.
CAS Number
– 1093070-16-6
Molecular Weight
– C20H20N2O
Compound Purity
– 0.9977
SMILES
– C[C@@H](NC(=O)c1cc(N)ccc1C)c1cccc2ccccc12
Target
– HDAC
Pathway
– Microbiology/Virology|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Ubiquitination
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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