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P2X3 antagonist 34
Price range: 1,728 CAD through 3,440 CAD
Products Details
Product Description
– P2X3 antagonist 34, a potent, selective, and orally active antagonist, targets the P2X3 homotrimeric receptor, exhibiting IC50s of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors respectively. It shows reduced activity against P2X2/3 heterotrimeric receptors across human, rat, and guinea pig models. Notably, this compound demonstrates a significant anti-tussive effect without altering taste[1].
Web ID
– T10560
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H26F2N4O3
References
– Garceau D, et al. BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration. Pulm Pharmacol Ther. 2019 Jun;56:56-62.
CAS Number
– 2417288-67-4
Molecular Weight
– C24H26F2N4O3
SMILES
– CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@@H]2CCCN(C2)C(=O)OC)c(F)c1
Target
– Parasite|||Cysteine Protease
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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