APTO-253
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APTO-253

SKU T10352-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 58 CAD through 1,006 CAD

Products Details

Product Description

– APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the KLF4 tumor suppressor.

Web ID

– T10352

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H14FN5

References

– Local A, et al. APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells. Mol Cancer Ther. 2018 Jun;17(6):1177-1186.

CAS Number

– 916151-99-0

Molecular Weight

– C22H14FN5

Compound Purity

– 0.9943

SMILES

– Cc1[nH]c2ccc(F)cc2c1-c1nc2c([nH]1)c1cccnc1c1ncccc21

Target

– Others

Pathway

– Apoptosis|||Cell Cycle/Checkpoint|||MAPK

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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