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Homocarnosine (TFA)
$200 – $1,950
Products Details
Product Description
– Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1]. Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2].
Web ID
– HY-114883A
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C12H17F3N4O5
References
– [1]Petroff OA, et al. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998;44(6):948-952.|[2]Kumrungsee T, et al. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles. Amino Acids. 2020;52(5):743-753.
Molecular Weight
– 354.28
Compound Purity
– 99.44
SMILES
– O=C(O)C(F)(F)F.O=C([C@@H](NC(CCCN)=O)CC1=CNC=N1)O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Endogenous Metabolite;GABA Receptor
Isoform
– Human Endogenous Metabolite
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
