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Celecoxib
Price range: 48 CAD through 347 CAD
Products Details
Product Description
– Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.
Web ID
– T0466
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C17H14F3N3O2S
Citations
– 1. Kazberuk A, Chalecka M, Palka J, et al. Nonsteroidal Anti-Inflammatory Drugs as PPARγ Agonists Can Induce PRODH/POX-Dependent Apoptosis in Breast Cancer Cells: New Alternative Pathway in NSAID-Induced Apoptosis. International Journal of Molecular Sciences. 2022, 23(3): 1510.
2. Zhang, Linhao, et al. Inhibition of cyclooxygenase‐2 enhanced intestinal epithelial homeostasis via suppressing β‐catenin signalling pathway in experimental liver fibrosis. Journal of Cellular and Molecular Medicine. 2021
3. Zhang L, Zhao C, Dai W, et al.Disruption of cholangiocyte-B cell crosstalk by blocking the CXCL12-CXCR4 axis alleviates liver fibrosis.Cellular and Molecular Life Sciences.2023, 80(12): 379.
4. Zheng X, Zhang C, Li L, et al.Improvement of astrocytic gap junction involves the anti-depressive effect of celecoxib through inhibition of NF-κB.Brain Research Bulletin.2024: 110871.
5. Xiang X, Wang K, Zhang H, et al.Blocking CX3CR1+ Tumor-associated Macrophages Enhances the Efficacy of Anti-PD-1 Therapy in Hepatocellular Carcinoma.Cancer Immunology Research.2024
References
– Liu DB, et al. Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation. Acta Pharmacol Sin. 2012 May;33(5):682-90.
CAS Number
– 169590-42-5
Molecular Weight
– C17H14F3N3O2S
Compound Purity
– 0.9998
SMILES
– C(F)(F)(F)C1=NN(C(=C1)C2=CC=C(C)C=C2)C3=CC=C(S(N)(=O)=O)C=C3
Target
– Others
Pathway
– Immunology/Inflammation|||Neuroscience
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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