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Disulfiram
Price range: 59 CAD through 112 CAD
Products Details
Product Description
– Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.15/1.45 μM) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore formation.
Web ID
– T0054
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C10H20N2S4
Citations
– 1. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797.
2. Yu S, Wang H, Liu M, et al. Loss of ATG5 in KRT14+ cells leads to accumulated functional impairments of salivary glands via pyroptosis. The FASEB Journal. 2022, 36(12): e22631.
3. Bowden G D, Land K M, O’Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Apr；8(1): 137-144
4. Yang Y, Zhu Y, Wang K, et al.Activation of autophagy by in situ Zn2+ chelation reaction for enhanced tumor chemoimmunotherapy.Bioactive Materials.2023, 29: 116-131.
5. Cui W, Guo M, Liu D, et al.Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition.Nature Cell Biology.2024: 1-14.
6. Zhang Z D, Shi C R, Li F X, et al.Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115.Cellular & Molecular Immunology.2024: 1-17.
7. Yuan X, Chen P, Luan X, et al.NLRP3 deficiency protects against acetaminophen‑induced liver injury by inhibiting hepatocyte pyroptosis.Molecular Medicine Reports.2024, 29(4): 1-15.
8. Liu Z, Dang B, Li Z, et al.Baicalin attenuates acute skin damage induced by ultraviolet B via inhibiting pyroptosis.Journal of Photochemistry and Photobiology B: Biology.2024: 112937.
9. Li M, Bei Z C, Yuan Y, et al.In-cell bioluminescence resonance energy transfer (BRET)-based assay uncovers ceritinib and CA-074 as SARS-CoV-2 papain-like protease inhibitors.Journal of Enzyme Inhibition and Medicinal Chemistry.2024, 39(1): 2387417.
References
– Nasrollahzadeh A, et al. Anti-proliferative activity of disulfiram through regulation of the AKT-FOXO axis: A proteomic study of molecular targets. Biochim Biophys Acta Mol Cell Res. 2021 Sep;1868(10):119087.
CAS Number
– 97-77-8
Molecular Weight
– C10H20N2S4
Compound Purity
– 0.9884
SMILES
– CCN(CC)C(=S)SSC(=S)N(CC)CC
Target
– Others
Pathway
– Apoptosis|||Immunology/Inflammation|||Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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