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Zoniporide (hydrochloride hydrate)
SKU
HY-105064D-1 mg
Category Reference compound
Tags Cardiovascular Disease, Membrane Transporter/Ion Channel, Na+/H+ Exchanger (NHE)
$160 – $820
Products Details
Product Description
– Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM)[1][2].
Web ID
– HY-105064D
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H19ClN6O2
Citations
– J Biol Chem. 2021 Sep 3;101166.|Carbohydr Polym. 1 January 2023, 120179.
References
– [1]Tracey WR, et al. Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc Drug Rev. 2003 Spring;21(1):17-32.|[2]Guzman-Perez A, et al. Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg Med Chem Lett. 2001 Mar 26;11(6):803-7.
CAS Number
– 863406-85-3
Molecular Weight
– 374.82
Compound Purity
– 99.0
SMILES
– O=C(C1=C(C2CC2)N(C3=C4C=CC=NC4=CC=C3)N=C1)NC(N)=N.[H]Cl.[H]O[H]
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– H2O : 2 mg/mL (ultrasonic;warming)
Target
– Na+/H+ Exchanger (NHE)
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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